Can Kryptonite affect Superman's mind?

I was watching Superman/Batman: Public Enemies, and Lex Luthor framed Superman for killing Metallo by stating that the gigantic asteroid made of kryptonite that was approaching Earth, was affecting his mind. It seemed like a part of his big speech to frame him, so I didn't pay attention. Later on, Batman asks him "Can it affect your mind?", to which Superman replies "No. I mean... It never has" which lead me to believe that he wasn't exactly sure about it. Does anyone know?